2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. TC-6683

TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder.

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TC-6683

TC-6683 Chemical Structure

CAS No. : 1025007-04-8

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Description

TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder[1][2].

Cellular Effect
Cell Line Type Value Description References
CHO EC50
70 μM
Compound: 4, AZD1446
Agonist activity at human alpha3beta4 nACHR expressed in CHO cell membranes assessed as stimulation of calcium flux by FLIPR assay
Agonist activity at human alpha3beta4 nACHR expressed in CHO cell membranes assessed as stimulation of calcium flux by FLIPR assay
[PMID: 23692872]
CHO EC50
70 μM
Compound: 56, TC-6683, AZD-1446
Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium flux by calcium4-based FLIPR assay
Agonist activity at human alpha3beta4 nAChR expressed in CHO cells assessed as calcium flux by calcium4-based FLIPR assay
[PMID: 22793665]
Clinical Trial
Molecular Weight

240.69

Formula

C11H13ClN2O2
CAS No.
SMILES

O=C(N1CC2CNCC2C1)C3=CC=C(Cl)O3
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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TC-6683 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-66831025007-04-8AZD1446TC6683TC 6683AZD 1446AZD-1446nAChRNicotinic acetylcholine receptorsnicotineDYT1dystoniacholinergic interneuronsdopaminemicrodialysiselectrophysiologyα4β2 nicotinic acetylcholine receptor agonistnon-desensitizing agonistInhibitorinhibitorinhibit

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