1036380-87-6
1036380-87-6
Chemical Structure
PIM-IN-4
- CAS No.: 1036380-87-6
- Formula:C19H17N3O2S
- Molecular Weight:351.42
IUPAC Name: 2-((dimethylamino)methyl)-8-(4-hydroxyphenyl)benzo[4,5]thieno[3,2-d]pyrimidin-4(1H)-one
InChIKey: PJNOYUGDEFSKQL-UHFFFAOYSA-N
SMILES: O=C1N=C(NC2=C1SC3=CC=C(C=C32)C=4C=CC(O)=CC4)CN(C)C
Biological Activity: PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research[1].
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PIM-IN-4 | PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research. | |||||||||||||||||||||
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References
Keywords
