2. JAK/STAT Signaling
  3. Pim
  4. PIM-IN-4

PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research.

For research use only. We do not sell to patients.

PIM-IN-4

PIM-IN-4 Chemical Structure

CAS No. : 1036380-87-6

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PIM-IN-4 Related Antibodies

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Description

PIM-IN-4 is a Pim kinase inhibitor with Ki values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research[1].

In Vitro

PIM-IN-4 (Compound 14j) (0.01-30 μM; 48 h) inhibits the proliferation of K562 and MV4-11 human leukemia cells with EC50 values of 1.7 μM and 2.4 μM, respectively[1].
PIM-IN-4 (4 h) inhibits Bad serine-112 phosphorylation in K562 human leukemia cells with an EC50 value of 0.5 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PIM-IN-4 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-∞ Cmax Tmax Bioavailability CL Vd T1/2
Mice[1] 3 mg/kg i.v. 1.10 μM·h / / / 7.80 L/h/kg 23.5 L/kg 2.10 h
Mice[1] 10 mg/kg p.o. 2.80 μM·h 0.52 μM 0.3 h 76 % / / /
Molecular Weight

351.42

Formula

C19H17N3O2S
CAS No.
SMILES

O=C1N=C(NC2=C1SC3=CC=C(C=C32)C=4C=CC(O)=CC4)CN(C)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PIM-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PIM-IN-41036380-87-6PimPim kinasesBadPim-1MV4-11Pim-2Pim kinaseCD-1 miceserine/threonine kinaseK562leukemia cellsPim-3Inhibitorinhibitorinhibit

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