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Cat. No.: HY-18088

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PIM-IN-4

PIM-IN-4 is a Pim kinase inhibitor with K_i values of 2, 3, and 0.5 nM against Pim-1, 2, 3, respectively. PIM-IN-4 blocks the phosphorylation of the pro-apoptotic protein Bad. PIM-IN-4 inhibits the growth of leukemia cells. PIM-IN-4 is applicable for leukemia-related research.

For research use only. We do not sell to patients.

CAS No.: 1036380-87-6
Formula: C₁₉H₁₇N₃O₂S
Molecular Weight:351.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-4 Chemical Structure

CAS No.: 1036380-87-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	EC₅₀	0.5 μM Compound: 14j	Inhibition of PIM in human K562 cells assessed as phospho-BAD protein levels after 2 hrs by immunoblotting Inhibition of PIM in human K562 cells assessed as phospho-BAD protein levels after 2 hrs by immunoblotting	[PMID: 19842661]
K562	EC₅₀	1.7 μM Compound: 14j	Antiproliferative activity against human K562 cells after 48 hrs by alamar blue assay Antiproliferative activity against human K562 cells after 48 hrs by alamar blue assay	[PMID: 19842661]
MV4-11	EC₅₀	2.4 μM Compound: 14j	Antiproliferative activity against human MV4-11 cells after 48 hrs by alamar blue assay Antiproliferative activity against human MV4-11 cells after 48 hrs by alamar blue assay	[PMID: 19842661]

In Vitro

PIM-IN-4 (Compound 14j) (0.01-30 μM; 48 h) inhibits the proliferation of K562 and MV4-11 human leukemia cells with EC₅₀ values of 1.7 μM and 2.4 μM, respectively^[1].
PIM-IN-4 (4 h) inhibits Bad serine-112 phosphorylation in K562 human leukemia cells with an EC₅₀ value of 0.5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	AUC_0-∞	C_max	T_max	Bioavailability	CL	V_d	T_1/2
Mice^[1]	3 mg/kg	i.v.	1.10 μM·h	/	/	/	7.80 L/h/kg	23.5 L/kg	2.10 h
Mice^[1]	10 mg/kg	p.o.	2.80 μM·h	0.52 μM	0.3 h	76 %	/	/	/

Chemical Information

CAS No. 1036380-87-6
Molecular Weight 351.42
Formula C₁₉H₁₇N₃O₂S
SMILES

O=C1N=C(NC2=C1SC3=CC=C(C=C32)C=4C=CC(O)=CC4)CN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Tao ZF, et al. Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases. J Med Chem. 2009;52(21):6621-6636. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PIM-IN-4

All Pim Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PIM-IN-4 Related Classifications

HY-18088 Related Classifications