1049741-81-2
Chemical Structure
Ciproxifan hydrochloride
Synonym(s): FUB-359 hydrochloride
- CAS. Nr.: 1049741-81-2
- Formula:C16H19ClN2O2
- Molecular Weight:306.79
IUPAC Name: (4-(3-(1H-imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone hydrochloride
InChIKey: PWAPSKMHZQQTRJ-UHFFFAOYSA-N
SMILES: O=C(C1CC1)C(C=C2)=CC=C2OCCCC3=CN=CN3.[H]Cl
Biological Activity: Ciproxifan (FUB 359) hydrochloride is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan hydrochloride displays low apparent affinity at other receptor subtypes. Ciproxifan hydrochloride can be used for the research of aging disorders and Alzheimer's disease[1][3].
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Ciproxifan hydrochloride | Ciproxifan (FUB 359) hydrochloride is a potent, selective, orally bioavailable and competitive antagonist of histamine H3-receptor, with an IC50 of 9.2 nM. Ciproxifan hydrochloride displays low apparent affinity at other receptor subtypes. Ciproxifan hydrochloride can be used for the research of aging disorders and Alzheimer's disease. | |||||||||||||||||||||
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- [1]. Ligneau X, et, al. Neurochemical and behavioral effects of ciproxifan, a potent histamine H3-receptor antagonist. J Pharmacol Exp Ther. 1998 Nov;287(2):658-66. [Content Brief]
- [3]. Mark E Bardgett, et al. Ciproxifan, an H3 receptor antagonist, alleviates hyperactivity and cognitive deficits in the APP Tg2576 mouse model of Alzheimer's disease. Neurobiol Learn Mem. 2011 Jan;95(1):64-72. [Content Brief]
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