1050381-35-5
Chemical Structure
BMS-694153
- CAS. Nr.: 1050381-35-5
- Formula:C35H45FN8O3
- Molecular Weight:644.78
IUPAC Name: (R)-N-(1-([1,4'-bipiperidin]-1'-yl)-3-(7-methyl-1H-indazol-5-yl)-1-oxopropan-2-yl)-4-(8-fluoro-2-oxo-1,4-dihydroquinazolin-3(2H)-yl)piperidine-1-carboxamide
InChIKey: HBOINTMVWRSZQS-SSEXGKCCSA-N
SMILES: O=C1N(C2CCN(CC2)C(N[C@@H](C(N3CCC(N4CCCCC4)CC3)=O)CC5=CC(C)=C(NN=C6)C6=C5)=O)CC7=CC=CC(F)=C7N1
Biological Activity: BMS-694153 is a potent antagonist of the human calcitonin gene-related peptide receptor (CGRP Receptor). BMS-694153 can be used for migraine with rapid and efficient intranasal exposure[1].
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BMS-694153 | BMS-694153 is a potent antagonist of the human calcitonin gene-related peptide receptor (CGRP Receptor). BMS-694153 can be used for migraine with rapid and efficient intranasal exposure. | |||||||||||||||||||||
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- [1]. Degnan AP, et al. Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure. J Med Chem. 2008 Aug 28;51(16):4858-61. [Content Brief]
Keywords
