105351-70-0
Chemical Structure
Tanshinlactone
- CAS No.: 105351-70-0
- Formula:C17H12O3
- Molecular Weight:264.28
IUPAC Name: 1,6-dimethyl-10H-benzo[h]furo[3,2-c]isochromen-10-one
InChIKey: VDYMGLBSIBHGCP-UHFFFAOYSA-N
SMILES: O=C1C2=C3C=CC=C(C)C3=CC=C2C(OC=C4C)=C4O1
Biological Activity: Tanshinlactone is a compound found in Salvia miltiorrhiza with anti-coronavirus (CoV) and anti-tumor activities. Tanshinlactone induces methuocytic cell death (methuosis) by activating the NRF2 pathway, and selectively kills ER+, HER2+/EGFR+ breast cancer cells. Tanshinlactone is applicable to research related to breast cancer and coronavirus infections[1][2].
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Tanshinlactone | Tanshinlactone is a compound found in Salvia miltiorrhiza with anti-coronavirus (CoV) and anti-tumor activities. Tanshinlactone induces methuocytic cell death (methuosis) by activating the NRF2 pathway, and selectively kills ER+, HER2+/EGFR+ breast cancer cells. Tanshinlactone is applicable to research related to breast cancer and coronavirus infections. | |||||||||||||||||||||
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- [1]. Lin W, et al. Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation. Front Pharmacol. 2025;15:1534217. Published 2025 Jan 21. [Content Brief]
- [2]. Rodrigues GCS, et al. Ligand and Structure-based Virtual Screening of Lamiaceae Diterpenes with Potential Activity against a Novel Coronavirus (2019-nCoV). Curr Top Med Chem. 2020;20(24):2126-2145. [Content Brief]
Keywords
