110300-77-1
110300-77-1
Chemical Structure
Taxamairin B
- CAS No.: 110300-77-1
- Formula:C22H24O4
- Molecular Weight:352.42
InChIKey: LDBQEVDAHSVWKL-UHFFFAOYSA-N
SMILES: CC(C1=C2)(C)C(C=CC1=CC3=C(C=C(C(C)C)C(OC)=C3OC)C2=O)=O
Biological Activity: Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice[1][2].
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Taxamairin B | Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice. | |||||||||||||||||||||
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References
- [1]. Liu M, et al. Rapid access to icetexane diterpenes: Their protective effects against lipopolysaccharides-induced acute lung injury via PI3K/AKT/NF-κB axis in macrophages. Eur J Med Chem. 2023 Nov 15;260:115769. [Content Brief]
- [2]. Liang JY, et al. Two new antineoplastic diterpenes from Taxus mairei. Chem Pharm Bull (Tokyo). 1987 Jun;35(6):2613-4. [Content Brief]
Keywords
