110590-60-8
Chemical Structure
Laminin peptide CDPGYIGSR
Synonym(s): Laminin (925-933)
- CAS No.: 110590-60-8
- Formula:C40H62N12O14S
- Molecular Weight:967.06
IUPAC Name: L-cysteinyl-L-aspartyl-L-prolylglycyl-L-tyrosyl-L-isoleucylglycyl-L-seryl-L-arginine
InChIKey: NGBBIWFVAWMQKZ-JDIVNGTKSA-N
SMILES: O=C(N(CCC1)[C@@H]1C(NCC(N[C@H](C(N[C@@H]([C@@H](C)CC)C(NCC(N[C@@H](CO)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)=O)=O)CC2=CC=C(O)C=C2)=O)=O)[C@H](CC(O)=O)NC([C@@H](N)CS)=O
Biological Activity: Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury[1][2][3][4][5].
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Laminin peptide CDPGYIGSR | Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury. | |||||||||||||||||||||
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- [1]. Massia SP, et al. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. The Journal of biological chemistry. 1993 Apr 15;268(11):8053-9. [Content Brief]
- [2]. Graf J, et al. A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochemistry. 1987 Nov 03;26(22):6896-900. [Content Brief]
- [3]. Bhagwat N, et al. Biofunctionalization of PEDOT films with laminin-derived peptides. Acta biomaterialia. 2016 Sep 01;41:235-46. [Content Brief]
- [4]. Castellano F, et al. An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1. Molecules (Basel, Switzerland). 2017 Dec 05;22(12):2151. [Content Brief]
- [5]. Itoh S, et al. Effects of a laminin peptide (YIGSR) immobilized on crab-tendon chitosan tubes on nerve regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. 2005 May;73(2):375-82. [Content Brief]
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