Laminin peptide CDPGYIGSR
Based on 1 Customer Validation
Laminin peptide CDPGYIGSR (Laminin (925-933)) is a peptide fragment derived from the laminin B1 chain that binds to laminin receptors, and acts as a ligand for the laminin receptor. Laminin peptide CDPGYIGSR mediates cell spreading, induces the clustering of receptors with vinculin and α-actinin, regulates the actin cytoskeleton, promotes the formation of stress fibers, and enhances epithelial cell adhesion. Laminin peptide CDPGYIGSR can be used in studies related to tumor metastasis and nerve injury.
For research use only. We do not sell to patients.
- Purity : 98.28%
- CAS No.: 110590-60-8
- Formula: C40H62N12O14S
- Molecular Weight:967.06
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Laminin peptide CDPGYIGSR promotes the adhesion of human fibrosarcoma HT-1080 cells, with a maximum adhesion rate of 64% at a concentration of 60 μg; in contrast, its amide form (CDPGYIGSR-NH2) achieves a maximum adhesion rate of 100% at the same concentration; modification of the arginine residue in CDPGYIGSR with 1,2-cyclohexanedione completely abolishes its adhesive activity[2].
Laminin peptide CDPGYIGSR confirms the presence of this peptide segment (with or without PEG spacer arms) on EA75 films[3].
Laminin peptide CDPGYIGSR is chemically conjugated to PEG10 to form PEG10-CDPGYIGSR. When immobilized on EA75 films, this conjugate significantly enhances PC2 cell adhesion capacity but fails to induce obvious neurite outgrowth without extra laminin coating; after laminin modification, it markedly boosts PC12 cell adhesion, neurite generation and average neurite length[3].
Laminin peptide CDPGYIGSR (YIGSR) binds non-covalently to t-chitosan/HAp tubes and covalently to t-chitosan/HAp-SH tubes[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 110590-60-8
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Appearance Solid
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Molecular Weight 967.06
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Formula C40H62N12O14S
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Synonyms
Laminin (925-933)
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Sequence
Cys-Asp-Pro-Gly-Tyr-Ile-Gly-Ser-Arg
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Sequence Shortening
CDPGYIGSR
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 50 mg/mL (51.70 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Massia SP, et al. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with alpha-actinin and vinculin. The Journal of biological chemistry. 1993 Apr 15;268(11):8053-9. [Content Brief]
[2]. Graf J, et al. A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochemistry. 1987 Nov 03;26(22):6896-900. [Content Brief]
[3]. Bhagwat N, et al. Biofunctionalization of PEDOT films with laminin-derived peptides. Acta biomaterialia. 2016 Sep 01;41:235-46. [Content Brief]
[4]. Castellano F, et al. An Overview of l-Amino Acid Oxidase Functions from Bacteria to Mammals: Focus on the Immunoregulatory Phenylalanine Oxidase IL4I1. Molecules (Basel, Switzerland). 2017 Dec 05;22(12):2151. [Content Brief]
[5]. Itoh S, et al. Effects of a laminin peptide (YIGSR) immobilized on crab-tendon chitosan tubes on nerve regeneration. Journal of biomedical materials research. Part B, Applied biomaterials. 2005 May;73(2):375-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.0341 mL | 5.1703 mL | 10.3406 mL | 25.8516 mL |
| 5 mM | 0.2068 mL | 1.0341 mL | 2.0681 mL | 5.1703 mL | |
| 10 mM | 0.1034 mL | 0.5170 mL | 1.0341 mL | 2.5852 mL | |
| 15 mM | 0.0689 mL | 0.3447 mL | 0.6894 mL | 1.7234 mL | |
| 20 mM | 0.0517 mL | 0.2585 mL | 0.5170 mL | 1.2926 mL | |
| 25 mM | 0.0414 mL | 0.2068 mL | 0.4136 mL | 1.0341 mL | |
| 30 mM | 0.0345 mL | 0.1723 mL | 0.3447 mL | 0.8617 mL | |
| 40 mM | 0.0259 mL | 0.1293 mL | 0.2585 mL | 0.6463 mL | |
| 50 mM | 0.0207 mL | 0.1034 mL | 0.2068 mL | 0.5170 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Laminin peptide CDPGYIGSR Related Classifications
HY-P0131 Related Classifications
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