111073-18-8
Chemical Structure
Nemazoline hydrochloride
Synonym(s): A-57219; SCH 40054
- CAS No.: 111073-18-8
- Formula:C10H12Cl3N3
- Molecular Weight:280.58
IUPAC Name: 2,6-dichloro-4-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride
InChIKey: ASIGTNNPGBMHLP-UHFFFAOYSA-N
SMILES: ClC1=C(N)C(Cl)=CC(CC2=NCCN2)=C1.Cl
Biological Activity: Nemazoline hydrochloride (A-57219 hydrochloride) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline hydrochloride produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline hydrochloride also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels[1].
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Nemazoline hydrochloride | Nemazoline hydrochloride (A-57219 hydrochloride) is selective α-adrenergic agent with α1-agonist/α2-antagonist activity, which is used as a nasal decongestant. Nemazoline hydrochloride produces decongestion by α1-mediated contraction of capacitance vessels, but not compromises blood flow by virtue of α2-antagonism. Nemazoline hydrochloride also blocks endogenous noradrenaline-mediated α 2-constriction of the resistance vessels. | |||||||||||||||||||||
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