1158221-32-9
Chemical Structure
D-159404
- CAS No.: 1158221-32-9
- Formula:C21H18ClFN2O2
- Molecular Weight:384.84
IUPAC Name: 1-(4-((3'-chloro-2-fluoro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea
InChIKey: YHCWLRRVAOFFFZ-UHFFFAOYSA-N
SMILES: O=C(N)NC1=CC=C(C=C1)CC=2C=CC(OC)=C(C3=CC=CC(Cl)=C3)C2F
Biological Activity: D-159404 is an orally active, blood-brain barrier-permeable, selective allosteric PDE4D inhibitor. It partially inhibits cAMP hydrolysis by binding to the UCR2 regulatory domain, elevates intracellular cAMP levels, and triggers calcium influx, thereby improving working memory and episodic memory consolidation. D-159404 is used in research on asthma, chronic obstructive pulmonary disease, and cognitive impairment[1][2][3].
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D-159404 | D-159404 is an orally active, blood-brain barrier-permeable, selective allosteric PDE4D inhibitor. It partially inhibits cAMP hydrolysis by binding to the UCR2 regulatory domain, elevates intracellular cAMP levels, and triggers calcium influx, thereby improving working memory and episodic memory consolidation. D-159404 is used in research on asthma, chronic obstructive pulmonary disease, and cognitive impairment. | |||||||||||||||||||||
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References
- [1]. Wunder F, et al. Characterization of the cellular activity of PDE 4 inhibitors using two novel PDE 4 reporter cell lines. Molecular pharmaceutics. 2013 Oct 07;10(10):3697-705. [Content Brief]
- [2]. Burgin AB, et al. Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nature biotechnology. 2010 Jan;28(1):63-70.
- [3]. Ti H, et al. Targeted Treatments for Chronic Obstructive Pulmonary Disease (COPD) Using Low-Molecular-Weight Drugs (LMWDs). Journal of medicinal chemistry. 2019 Jul 11;62(13):5944-5978. [Content Brief]
