116819-28-4
116819-28-4
Chemical Structure
Methotrexate-alpha-alanine
- CAS No.: 116819-28-4
- Formula:C23H27N9O6
- Molecular Weight:525.52
InChIKey: IYWOCQLKOJVCQN-NHYWBVRUSA-N
SMILES: NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@@H](CCC(O)=O)C(N[C@@H](C)C(O)=O)=O)=O)C)C=N2
Biological Activity: Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates of Methotrexate (HY-14519). Methotrexate-alpha-alanine shows cytotoxicity[1][2].
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Methotrexate-alpha-alanine | Methotrexate-alpha-alanine is a prodrug for activation by enzyme-monoclonal antibody conjugates of Methotrexate (HY-14519). Methotrexate-alpha-alanine shows cytotoxicity. | |||||||||||||||||||||
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References
- [1]. Haenseler E, et al. Activation of methotrexate-alpha-alanine by carboxypeptidase A-monoclonal antibody conjugate. Biochemistry. 1992 Jan 28;31(3):891-7. [Content Brief]
- [2]. Huennekens FM. Development of methotrexate alpha-peptides as prodrugs for activation by enzyme-monoclonal antibody conjugates. Adv Enzyme Regul. 1997;37:77-92. [Content Brief]
Keywords
