118790-68-4
118790-68-4
Chemical Structure
SIM-6080
- CAS No.: 118790-68-4
- Formula:C29H36F2N2O3
- Molecular Weight:498.60
IUPAC Name: N1-(3,3-bis(4-fluorophenyl)propyl)-N1,N2-dimethyl-N2-(3,4,5-trimethoxybenzyl)ethane-1,2-diamine
InChIKey: NOMSFNRBXCWAIE-UHFFFAOYSA-N
SMILES: FC1=CC=C(C(CCN(CCN(CC2=CC(OC)=C(C(OC)=C2)OC)C)C)C3=CC=C(C=C3)F)C=C1
Biological Activity: SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits[1][2].
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SIM-6080 | SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits. | |||||||||||||||||||||
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References
- [1]. Bernini F, et al. In vitro inhibition of arterial myocyte growth and stimulation of low density lipoprotein metabolism by SIM 6080, a new calcium antagonist. Pharmacol Res. 1990;22(1):27-35. [Content Brief]
- [2]. Maggi FM, et al. SIM 6080, a new calcium antagonist, reduces aortic atherosclerosis in cholesterol-fed rabbits. Pharmacol Res. 1993;28(3):219-227. [Content Brief]
Keywords
