1191888-51-3
1191888-51-3
Chemical Structure
Felbamate-d5
Synonym(s): Felbamyl-d5;Felbatol-d5;Taloxa-d5
- CAS No.: 1191888-51-3
- Formula:C11H9D5N2O4
- Molecular Weight:243.27
IUPAC Name: 2-(phenyl-d5)propane-1,3-diyl dicarbamate
InChIKey: WKGXYQFOCVYPAC-RALIUCGRSA-N
SMILES: NC(OCC(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])COC(N)=O)=O
Biological Activity: Felbamate-d5 is the deuterium labeled Felbamate[1]. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA)[2][3].
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Felbamate-d5 | Felbamate-d5 is the deuterium labeled Felbamate. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). | |||||||||||||||||||||
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Felbamate (Standard) | ≥98% | Felbamate (Standard) is the analytical standard of Felbamate. This product is intended for research and analytical applications. Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). | ||||||||||||||||||||
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Felbamate-d4 | 97.20% | Felbamate-d4 (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). | ||||||||||||||||||||
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Felbamate | 99.48% | Felbamate (W-554) is a potent nonsedative anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA). | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65(2):370-80. [Content Brief]
- [3]. Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. [Content Brief]
