Felbamate-d4
Based on 1 Customer Validation
Felbamate-d4 (W-554-d4) is the deuterium labeled Felbamate. Felbamate (W-554) is a potent anticonvulsant whose clinical effect may be related to the inhibition of N-methyl-D-aspartate (NMDA).
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 97.20%
- CAS No.: 106817-52-1
- 화학식: C11H10D4N2O4
- 분자량:242.26
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보관:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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NMDA Receptor |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 106817-52-1
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Unlabeled Cas 25451-15-4
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Appearance Solid
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분자량 242.26
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화학식 C11H10D4N2O4
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Color White to off-white
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SMILES
C(C(OC(N)=O)([2H])[2H])(C(OC(N)=O)([2H])[2H])C1=CC=CC=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
DMF : ≥ 50 mg/mL (206.39 mM)
DMSO : ≥ 30 mg/mL (123.83 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : ≥ 1 mg/mL (4.13 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Kuo CC, et al. Use-dependent inhibition of the N-methyl-D-aspartate currents by felbamate: a gating modifier with selective binding to the desensitized channels. Mol Pharmacol. 2004 Feb;65(2):370-80. [Content Brief]
[3]. Harty TP, et al. Felbamate block of recombinant N-methyl-D-aspartate receptors: selectivity for the NR2B subunit. Epilepsy Res. 2000 Mar;39(1):47-55. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO / DMF | 1 mM | 4.1278 mL | 20.6390 mL | 41.2780 mL | 103.1949 mL |
| DMSO / DMF | 5 mM | 0.8256 mL | 4.1278 mL | 8.2556 mL | 20.6390 mL |
| 10 mM | 0.4128 mL | 2.0639 mL | 4.1278 mL | 10.3195 mL | |
| 15 mM | 0.2752 mL | 1.3759 mL | 2.7519 mL | 6.8797 mL | |
| 20 mM | 0.2064 mL | 1.0319 mL | 2.0639 mL | 5.1597 mL | |
| 25 mM | 0.1651 mL | 0.8256 mL | 1.6511 mL | 4.1278 mL | |
| 30 mM | 0.1376 mL | 0.6880 mL | 1.3759 mL | 3.4398 mL | |
| 40 mM | 0.1032 mL | 0.5160 mL | 1.0319 mL | 2.5799 mL | |
| 50 mM | 0.0826 mL | 0.4128 mL | 0.8256 mL | 2.0639 mL | |
| 60 mM | 0.0688 mL | 0.3440 mL | 0.6880 mL | 1.7199 mL | |
| 80 mM | 0.0516 mL | 0.2580 mL | 0.5160 mL | 1.2899 mL | |
| 100 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 1.0319 mL |
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