12001-72-8
Chemical Structure
Mafenide propionate
- CAS No.: 12001-72-8
- Formula:C10H16N2O4S
- Molecular Weight:260.31
InChIKey: SVJKMLBXJJZCHN-UHFFFAOYSA-N
SMILES: O=C(CC)O.O=S(N)(C1=CC=C(CN)C=C1)=O
Biological Activity: Mafenide propionate is a dual inhibitor of dihydropteroate synthase (Dihydropteroate synthase) and carbonic anhydrase (Carbonic anhydrase). Mafenide propionate disrupts nucleotide biosynthesis by inhibiting the de novo base synthesis pathway, thereby exerting broad-spectrum antibacterial and cytotoxic effects without inducing mutations. Mafenide propionate can be used for wound assessment and promotes the formation of healthy granulation tissue, making it suitable for scenarios such as mesh skin grafting. Mafenide propionate has been widely used in studies on diseases associated with burn wound infections, acute and chronic wounds, blast injuries, open fractures, and necrotizing fasciitis[1][2].
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Mafenide propionate | Mafenide propionate is a dual inhibitor of dihydropteroate synthase (Dihydropteroate synthase) and carbonic anhydrase (Carbonic anhydrase). Mafenide propionate disrupts nucleotide biosynthesis by inhibiting the de novo base synthesis pathway, thereby exerting broad-spectrum antibacterial and cytotoxic effects without inducing mutations. Mafenide propionate can be used for wound assessment and promotes the formation of healthy granulation tissue, making it suitable for scenarios such as mesh skin grafting. Mafenide propionate has been widely used in studies on diseases associated with burn wound infections, acute and chronic wounds, blast injuries, open fractures, and necrotizing fasciitis. | |||||||||||||||||||||
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- [1]. Krátký M, et al.. Improving the antimicrobial activity of old antibacterial drug mafenide: Schiff bases and their bioactivity targeting resistant pathogens. Future medicinal chemistry. 2023 Feb;15(3):255-274. [Content Brief]
- [2]. Barillo D J. Using mafenide acetate in acute and chronic wounds[J]. OSTOMY WOUND MANAGEMENT, 2002, 48(9; SUPP): 5-10.
Keywords
