1210608-87-9
1210608-87-9
Chemical Structure
Lapatinib-13C,d7
Synonym(s): GW572016-13C,d7; GW2016-13C,d7
- CAS No.: 1210608-87-9
- Formula:C2813CH19D7ClFN4O4S
- Molecular Weight:589.09
InChIKey: BCFGMOOMADDAQU-FFSONIBRSA-N
SMILES: [2H][13C]([2H])([2H])S(C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=NC=N5)=C5C=C2)(=O)=O
Biological Activity: Lapatinib-13C,d7 (GW572016-13C,d7) is the deuterium and 13C-labeled Lapatinib (HY-50898). Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
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Lapatinib-13C,d7 | Lapatinib-13C,d7 (GW572016-13C,d7) is the deuterium and 13C-labeled Lapatinib (HY-50898). Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib (Standard) | 99.69% | Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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Lapatinib-d4-1 | Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-d4 | 99.02% | Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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Lapatinib-d5 | Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-d7 dihydrochloride | Lapatinib-d7 dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-d7 | Lapatinib-d7 (GW572016-d7) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib | 99.83% | Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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