Lapatinib-d4
Based on 1 Customer Validation
Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.02%
- CAS No.: 1184263-99-7
- Formula: C29H22D4ClFN4O4S
- Molecular Weight:585.08
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1184263-99-7
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Unlabeled Cas 231277-92-2
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Appearance Solid
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Molecular Weight 585.08
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Formula C29H22D4ClFN4O4S
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Color Light yellow to yellow
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SMILES
CS(C([2H])([2H])C([2H])([2H])NCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=CC(F)=CC=C4)=NC=N5)=C5C=C2)(=O)=O
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Synonyms
GW572016-d4; GW2016-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (213.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7092 mL | 8.5458 mL | 17.0917 mL | 42.7292 mL |
| 5 mM | 0.3418 mL | 1.7092 mL | 3.4183 mL | 8.5458 mL | |
| 10 mM | 0.1709 mL | 0.8546 mL | 1.7092 mL | 4.2729 mL | |
| 15 mM | 0.1139 mL | 0.5697 mL | 1.1394 mL | 2.8486 mL | |
| 20 mM | 0.0855 mL | 0.4273 mL | 0.8546 mL | 2.1365 mL | |
| 25 mM | 0.0684 mL | 0.3418 mL | 0.6837 mL | 1.7092 mL | |
| 30 mM | 0.0570 mL | 0.2849 mL | 0.5697 mL | 1.4243 mL | |
| 40 mM | 0.0427 mL | 0.2136 mL | 0.4273 mL | 1.0682 mL | |
| 50 mM | 0.0342 mL | 0.1709 mL | 0.3418 mL | 0.8546 mL | |
| 60 mM | 0.0285 mL | 0.1424 mL | 0.2849 mL | 0.7122 mL | |
| 80 mM | 0.0214 mL | 0.1068 mL | 0.2136 mL | 0.5341 mL | |
| 100 mM | 0.0171 mL | 0.0855 mL | 0.1709 mL | 0.4273 mL |
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