1216621-00-9
Chemical Structure
Trap-101 hydrochloride
- CAS No.: 1216621-00-9
- Formula:C24H36ClN3O2
- Molecular Weight:434.01
IUPAC Name: 1-(1-(cyclooctylmethyl)-5-(hydroxymethyl)-1,2,3,6-tetrahydropyridin-4-yl)-3-ethyl-1,3-dihydro-2H-benzo[d]imidazol-2-one hydrochloride
InChIKey: YEVMLMQAMCKVSC-UHFFFAOYSA-N
SMILES: O=C1N(CC)C2=CC=CC=C2N1C3=C(CO)CN(CC4CCCCCCC4)CC3.[H]Cl
Biological Activity: Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ-, and δ-opioid receptors, respectively. Trap-101 attenuates motor deficits in a rat model of parkinson's disease and can be used for the research of nervous system diseases[1].
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Trap-101 hydrochloride | Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and <5 for NOP, μ-, κ-, and δ-opioid receptors, respectively. Trap-101 attenuates motor deficits in a rat model of parkinson's disease and can be used for the research of nervous system diseases. | |||||||||||||||||||||
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Keywords
