121839-78-9
121839-78-9
Chemical Structure
(-)-Ibuprofenamide
Synonym(s): (R)-Ibuprofenamide
- CAS No.: 121839-78-9
- Formula:C13H19NO
- Molecular Weight:205.30
IUPAC Name: (R)-2-(4-isobutylphenyl)propanamide
InChIKey: REUQKCDCQVNKLW-SNVBAGLBSA-N
SMILES: CC(C)CC1=CC=C([C@@H](C)C(N)=O)C=C1
Biological Activity: (-)-Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity[1]. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively[2].
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(-)-Ibuprofenamide | (-)-Ibuprofenamide is an amide proagent of Ibuprofen with anti-inflammatory activity. Ibuprofen is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively. | |||||||||||||||||||||
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References
- [1]. Shanbhag VR, et al. Ester and amide prodrugs of ibuprofen and naproxen: synthesis, anti-inflammatory activity, and gastrointestinal toxicity. J Pharm Sci. 1992 Feb;81(2):149-54. [Content Brief]
- [2]. Noreen Y, et al. Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. J Nat Prod. 1998 Jan;61(1):2-7. [Content Brief]
Keywords
