1219795-09-1
Chemical Structure
N-Isovaleroylglycine-d2
- CAS No.: 1219795-09-1
- Formula:C7H11D2NO3
- Molecular Weight:161.20
IUPAC Name: (3-methylbutanoyl)glycine-2,2-d2
InChIKey: ZRQXMKMBBMNNQC-APZFVMQVSA-N
SMILES: OC(C([2H])([2H])NC(CC(C)C)=O)=O
Biological Activity: N-Isovaleroylglycine-d2 is the deuterium labeled N-Isovaleroylglycine (HY-W015464). N-Isovaleroylglycine is a peptidylglycine α-amidating monooxygenase (PAM) inhibitor with a Ki value of 2.0 mM against human hsPAM. N-Isovaleroylglycine undergoes oxidative cleavage by purified rat PAM to produce fatty acid amide and glyoxylic acid. N-Isovaleroylglycine exerts competitive inhibition by binding to hsPAM, blocking the amidation of dansyl-Tyr-Val-Gly. N-Isovaleroylglycine exhibits lowered urinary abundance in MRSA-infected mice, which qualifies it as a non-invasive biomarker. N-Isovaleroylglycine can be used in studies related to Staphylococcus aureus pneumonia and diabetic foot[1][2][3].
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N-Isovaleroylglycine-d2 | N-Isovaleroylglycine-d2 is the deuterium labeled N-Isovaleroylglycine (HY-W015464). N-Isovaleroylglycine is a peptidylglycine α-amidating monooxygenase (PAM) inhibitor with a Ki value of 2.0 mM against human hsPAM. N-Isovaleroylglycine undergoes oxidative cleavage by purified rat PAM to produce fatty acid amide and glyoxylic acid. N-Isovaleroylglycine exerts competitive inhibition by binding to hsPAM, blocking the amidation of dansyl-Tyr-Val-Gly. N-Isovaleroylglycine exhibits lowered urinary abundance in MRSA-infected mice, which qualifies it as a non-invasive biomarker. N-Isovaleroylglycine can be used in studies related to Staphylococcus aureus pneumonia and diabetic foot. | |||||||||||||||||||||
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Keywords
