1221408-42-9
1221408-42-9
Chemical Structure
YQA14
- CAS No.: 1221408-42-9
- Formula:C23H27ClN4O3
- Molecular Weight:442.94
IUPAC Name: N-(4-(4-(5-chloro-2-methylphenyl)piperazin-1-yl)butyl)-2-oxo-2,3-dihydrobenzo[d]oxazole-5-carboxamide
InChIKey: VIZDBZXBKIEXRK-UHFFFAOYSA-N
SMILES: O=C(NCCCCN1CCN(CC1)C2=CC(Cl)=CC=C2C)C3=CC=C4OC(NC4=C3)=O
Biological Activity: YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals[1][2].
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YQA14 | 98.62% | YQA14 is a high affinity dopamine D3 receptor antagonist. YQA14 is anti-opioid addiction agent. YQA14 inhibits Morphine/Cocaine-induced conditioned place preference (CPP) in animals. | ||||||||||||||||||||
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References
- [1]. Hu R, et al. The dopamine D3 receptor antagonist YQA14 that inhibits the expression and drug-primed reactivation of morphine-induced conditioned place preference in rats. Eur J Pharmacol. 2013 Oct 24:S0014-2999(13)00782-6. [Content Brief]
- [2]. Song R, et al. Dopamine D(3) receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice. Neuropharmacology. 2013 Sep;72:82-7. [Content Brief]
Keywords
