1221418-42-3
1221418-42-3
Chemical Structure
SAR629
- CAS No.: 1221418-42-3
- Formula:C20H19F2N5O
- Molecular Weight:383.39
IUPAC Name: (4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone
InChIKey: UIOVHJYJUUSVIG-UHFFFAOYSA-N
SMILES: O=C(N1N=CN=C1)N2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
Biological Activity: SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SAR629 | 99.93% | SAR629 is a potent monoglyceride lipase (MGL) covalent inhibitor. SAR629 also inhibits 2-Arachidonoylglycerol (2-AG) degradation. | ||||||||||||||||||||
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References
- [1]. Niina Aaltonen, et al. Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase. Chem Biol. 2013 Mar 21;20(3):379-90. [Content Brief]
- [2]. T Bertrand, et al. Structural basis for human monoglyceride lipase inhibition. J Mol Biol. 2010 Feb 26;396(3):663-73. [Content Brief]
Keywords
