1222878-02-5
1222878-02-5
Chemical Structure
ML169
Synonym(s): VU0405652
- CAS No.: 1222878-02-5
- Formula:C21H17BrFN3O4S
- Molecular Weight:506.34
IUPAC Name: 2-((1-(5-bromo-2-fluorobenzyl)-1H-indol-3-yl)sulfonyl)-N-(5-methylisoxazol-3-yl)acetamide
InChIKey: RUYRNYRGPSAXTK-UHFFFAOYSA-N
SMILES: O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
Biological Activity: ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].
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ML169 | ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease. | |||||||||||||||||||||
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References
Keywords
