ML169
ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 1222878-02-5
- Formula: C21H17BrFN3O4S
- Molecular Weight:506.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 1.38 µM (M1 mAChR)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
1.38 μM
Compound: 15j, VU0405652, ML169
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Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
Allosteric modulation at rat M1 receptor expressed in CHO cells by calcium mobilization assay
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[PMID: 21194936] |
ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway[1].
ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1222878-02-5
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Molecular Weight 506.34
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Formula C21H17BrFN3O4S
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SMILES
O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4
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Synonyms
VU0405652
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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