1. GPCR/G Protein
    Neuronal Signaling
  2. mAChR
  3. ML169

ML169 (Synonyms: VU0405652)

Cat. No.: HY-120576
Handling Instructions

ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease.

For research use only. We do not sell to patients.

ML169 Chemical Structure

ML169 Chemical Structure

CAS No. : 1222878-02-5

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Description

ML169 (VU0405652) is a potent, selective and brain penetrant positive allosteric modulator (PAM) of M1 mAChR, with an EC50 of 1.38 µM. ML169 is a MLPCN probe and can be used for Alzheimer’s disease[1].

IC50 & Target

EC50: 1.38 µM (M1 mAChR)[1]

In Vitro

ML169 (VU0405652) is selective versus the biogenic amines (D2, H-HT2B, etc...) and displays no orthosteric binding at M1–M5[1].
ML169 shifts APP processing towards a non-amyloidogenic pathway[1].
ML169 (2 µM) potentiates the carbachol (CCh)-mediated non-amyloidogenic APPsa release to the same degree as 10 µM CCh[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ML169 (VU0405652) (10 mg/kg; i.p.) affords a brainAUC/plasmaAUC of 0.32 at 1 h in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

506.34

Formula

C21H17BrFN3O4S

CAS No.
SMILES

O=C(CS(=O)(C1=CN(C2=C1C=CC=C2)CC3=CC(Br)=CC=C3F)=O)NC4=NOC(C)=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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