1227056-84-9
1227056-84-9
Chemical Structure
Ampreloxetine
Synonym(s): TD-9855
- CAS No.: 1227056-84-9
- Formula:C18H18F3NO
- Molecular Weight:321.34
IUPAC Name: 4-(2-((2,4,6-trifluorophenoxy)methyl)phenyl)piperidine
InChIKey: TZIALEBTHQWNAO-UHFFFAOYSA-N
SMILES: FC1=C(OCC2=CC=CC=C2C3CCNCC3)C(F)=CC(F)=C1
Biological Activity: Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ampreloxetine | 98.64% | Ampreloxetine (TD-9855) is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension. | ||||||||||||||||||||
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References
- [1]. Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. [Content Brief]
- [2]. Kaufmann H, et al. Safety and efficacy of ampreloxetine in symptomatic neurogenic orthostatic hypotension: a phase 2 trial. Clin Auton Res. 2021 Dec;31(6):699-711. [Content Brief]
Keywords
