122799-38-6
Chemical Structure
2'-Fluorothymidine
Synonym(s): 2'-Deoxy-2'-fluoro-5-Methyluridine
- CAS No.: 122799-38-6
- Formula:C10H13FN2O5
- Molecular Weight:260.22
IUPAC Name: 1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
InChIKey: GBBJCSTXCAQSSJ-JXOAFFINSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(C(C)=C2)=O)=O)O1
Biological Activity: 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research[1].
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2'-Fluorothymidine | 99.07% | 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research. | ||||||||||||||||||||
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2'-Fluorothymidine (Standard) | ≥98% | 2'-Fluorothymidine (Standard) is the analytical standard of 2'-Fluorothymidine. This product is intended for research and analytical applications. 2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine) is a nucleoside analog and hCNT inhibitor, with an IC50 of 1.1 μM against hCNT1 and an IC50 of 9.7 μM against hCNT3. 2'-Fluorothymidine undergoes phosphorylation by cytosolic thymidine kinase (TK1) and mitochondrial thymidine kinase (TK2). 2'-Fluorothymidine acts as a backbone stabilizer in oligonucleotide synthesis and can also form radiolabeled candidates. 2'-Fluorothymidine is applicable in tumor-related research. | ||||||||||||||||||||
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