1228013-30-6
1228013-30-6
Chemical Structure
Onatasertib
Synonym(s): CC-223; ATG-008
- CAS. Nr.: 1228013-30-6
- Formula:C21H27N5O3
- Molecular Weight:397.47
IUPAC Name: 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((1r,4r)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one
InChIKey: UFKLYTOEMRFKAD-SHTZXODSSA-N
SMILES: O=C1CNC2=NC=C(C3=CC=C(C(C)(O)C)N=C3)N=C2N1[C@H]4CC[C@H](OC)CC4
Biological Activity: Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2.
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Onatasertib | 99.47% | Onatasertib (CC-223) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase, with an IC50 value for mTOR kinase of 16 nM. Onatasertib inhibits both mTORC1 and mTORC2. | ||||||||||||||||||||
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Keywords
