1228559-81-6
Chemical Structure
Linaprazan glurate
Synonym(s): X842
- CAS No.: 1228559-81-6
- Formula:C26H32N4O5
- Molecular Weight:480.56
IUPAC Name: tert-butyl methyl-L-alaninate
InChIKey: GPHPBXRKAJSSIC-UHFFFAOYSA-N
SMILES: O=C(CCCC(OCCNC(C1=CN2C(C)=C(C)N=C2C(NCC3=C(C)C=CC=C3C)=C1)=O)=O)O
Biological Activity: Linaprazan glurate (X842) is an orally atcive prodrug of Linaprazan (HY-100412) with a potent and prolonged inhibitory effect on gastric acid secretion. Linaprazan glurate is rapidly transformed by enzymatic cleavage into its active metabolite, linaprazan. Linaprazan glurate is a potassium-competitive acid blocker. Linaprazan glurate selectively inhibites acid formation from gastric H⁺/K⁺-ATPase in a potassium-dependent manner (IC50 = 436.2 nM). Linaprazan glurate can be used for the studies of erosive esophagitis (EE)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Linaprazan glurate | 99.65% | Linaprazan glurate (X842) is an orally atcive prodrug of Linaprazan (HY-100412) with a potent and prolonged inhibitory effect on gastric acid secretion. Linaprazan glurate is rapidly transformed by enzymatic cleavage into its active metabolite, linaprazan. Linaprazan glurate is a potassium-competitive acid blocker. Linaprazan glurate selectively inhibites acid formation from gastric H⁺/K⁺-ATPase in a potassium-dependent manner (IC50 = 436.2 nM). Linaprazan glurate can be used for the studies of erosive esophagitis (EE). | ||||||||||||||||||||
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- [1]. Lu M, et al. Pharmacological characterization of linaprazan glurate (X842), a novel potassium-competitive acid blocker, in vitro and in vivo. Front Pharmacol. 2025 Sep 5;16:1636523. [Content Brief]
- [2]. Zhang X, et al. Absorption, distribution, metabolism and excretion of linaprazan glurate in rats. J Pharm Biomed Anal. 2024 May 15;242:116012. [Content Brief]
Keywords
