1229238-69-0
1229238-69-0
Chemical Structure
hDDAH-1-IN-1
- CAS No.: 1229238-69-0
- Formula:C8H20N4O
- Molecular Weight:188.27
IUPAC Name: 1-(4-aminobutyl)-3-(2-methoxyethyl)guanidine
InChIKey: SJQJFADASWPDIQ-UHFFFAOYSA-N
SMILES: N=C(NCCOC)NCCCCN
Biological Activity: hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM. DDAH mediates ADMA metabolism, thereby regulating nitric oxide production in a variety of disease states[1][2].
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hDDAH-1-IN-1 | hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM. DDAH mediates ADMA metabolism, thereby regulating nitric oxide production in a variety of disease states. | |||||||||||||||||||||
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References
- [1]. Tran CT, et al. The DDAH/ADMA/NOS pathway. Atheroscler Suppl. 2003 Dec;4(4):33-40. [Content Brief]
- [2]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31. [Content Brief]
Keywords
