hDDAH-1-IN-1
hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM. DDAH mediates ADMA metabolism, thereby regulating nitric oxide production in a variety of disease states.
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- CAS. Nr.: 1229238-69-0
- Formel: C8H20N4O
- Molecular Weight:188.27
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
Ki: 18 µM (hDDAH-1)[1]
Chemical Information
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CAS. Nr. 1229238-69-0
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Molecular Weight 188.27
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Formel C8H20N4O
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SMILES
N=C(NCCOC)NCCCCN
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Tran CT, et al. The DDAH/ADMA/NOS pathway. Atheroscler Suppl. 2003 Dec;4(4):33-40. [Content Brief]
[2]. Lunk I, et al. Discovery of N-(4-Aminobutyl)-N'-(2-methoxyethyl)guanidine as the First Selective, Nonamino Acid, Catalytic Site Inhibitor of Human Dimethylarginine Dimethylaminohydrolase-1 (hDDAH-1). J Med Chem. 2019 Dec 31. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
hDDAH-1-IN-1 Related Classifications
HY-133126 Related Classifications
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