123060-40-2
Chemical Structure
1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine
Synonym(s): 14:0 Lyso PE; 1-Myristoyl-2-hydroxy-sn-glycero-3-PE; 1-Tetradecanoyl-sn-glycero-3-phosphoethanolamine
- CAS No.: 123060-40-2
- Formula:C19H40NO7P
- Molecular Weight:425.50
IUPAC Name: (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-hydroxypropyl tetradecanoate
InChIKey: RPXHXZNGZBHSMJ-GOSISDBHSA-N
SMILES: CCCCCCCCCCCCCC(OC[C@@H](O)COP(OCCN)(O)=O)=O
Biological Activity: 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells [1]. Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls[2].
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1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine | 99.07% | 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . Serum levels of 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine are elevated in patients with malignant breast cancer compared to healthy controls. | ||||||||||||||||||||
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1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27 | 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine-d27 (14:0 Lyso PE-d27) is the deuterium labeled 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine. 1-Myristoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine (14:0 Lyso PE) is a lysophospholipid with a phosphoethanolamine head and a myristoyl tail. The free amine group can conjugate with NHS active ester or coupled with carboxylic acid in the presence of a coupling agent. It also induces transient increases in intracellular calcium in PC12 cells . | |||||||||||||||||||||
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- [1]. Lee, J.M., Park, S.J., and Im, D.S. Lysophosphatidylethanolamine increases intracellular Ca2+ through LPA1 in PC-12 neuronal cells. Biochem. Biophys. Res. Commun. 461(2), 378-382 (2015). [Content Brief]
- [2]. More, T.H., Bagadi, M., RoyChoudhury, S., et al. Comprehensive quantitative lipidomic approach to investigate serum phospholipid alterations in breast cancer. Metabolomics 13:3, (2017).
