123598-19-6
Chemical Structure
DT-5461
- CAS No.: 123598-19-6
- Formula:C73H133N4O22P
- Molecular Weight:1449.82
InChIKey: UJHMVJBHIMKLDF-BBAFUJFLSA-N
SMILES: CCCCCCCCCCCCCC(N[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1OC[C@H]2O[C@@H]([C@@H]([C@H]([C@@H]2O)OC(CNC(CCCCCCCCCCC)=O)=O)NC(CCCCCCCCCCCCC)=O)OC(CC(O)=O)CC(O)=O)CO)OP(O)(O)=O)OC(CNC(CCCCCCCCCCC)=O)=O)=O
Biological Activity: DT-5461 is an IL-1 and TNF-α antagonist. DT-5461 competitively binds lipid A-binding sites on macrophage receptors, blocks LPS (HY-D1056)-initiated signaling, inhibits LPS-induced cytokine release, prevents LPS-induced serum cytokine production in mice, and protects against LPS-induced lethal endotoxemia. DT-5461 can be used for the research of lethal endotoxemia, medullary tubular mammary carcinoma, poorly differentiated colon adenocarcinoma, squamous-cell lung carcinoma, and gelatinous gastric adenocarcinoma[1][2][3].
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DT-5461 | DT-5461 is an IL-1 and TNF-α antagonist. DT-5461 competitively binds lipid A-binding sites on macrophage receptors, blocks LPS (HY-D1056)-initiated signaling, inhibits LPS-induced cytokine release, prevents LPS-induced serum cytokine production in mice, and protects against LPS-induced lethal endotoxemia. DT-5461 can be used for the research of lethal endotoxemia, medullary tubular mammary carcinoma, poorly differentiated colon adenocarcinoma, squamous-cell lung carcinoma, and gelatinous gastric adenocarcinoma. | |||||||||||||||||||||
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- [1]. Sato K, et al. A novel synthetic lipid A analog with low endotoxicity, DT-5461, prevents lethal endotoxemia. Infect Immun. 1995;63(8):2859-2866. [Content Brief]
- [2]. Sagara-Ishijima N, et al. Toxic characteristics of the synthetic lipid A derivative DT-5461 in rats and monkeys. Toxicol Sci. 1999;49(2):324-331. [Content Brief]
- [3]. Kumazawa E, et al. Antitumor effect of DT-5461, a lipid A derivative, against human tumor xenografts is mediated by intratumoral production of tumor necrosis factor and affected by host immunosuppressive factors in nude mice. Cancer Invest. 1997;15(6):522-530. [Content Brief]
Keywords
