125139-67-5
Chemical Structure
Polyphemusin I
- CAS No.: 125139-67-5
- Formula:C108H161N39O20S4
- Molecular Weight:2453.94
IUPAC Name: (1R,4S,7S,10S,13R,18R,21S,24S,27S,30R,33S,39S,42S)-N-((S)-1-amino-5-guanidino-1-oxopentan-2-yl)-13-((S)-2-((S)-2-((S)-2-amino-5-guanidinopentanamido)-5-guanidinopentanamido)-3-(1H-indol-3-yl)propanamido)-21-(4-aminobutyl)-10,33-dibenzyl-7,24,39-tris(3-gua
InChIKey: VUSKVIGHZDQIDY-MTHDQZMLSA-N
SMILES: O=C1N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@]3(C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC5=CC=CC=C5)C(N[C@@]([H])(CSSC3)C(N[C@@H](CC6=CC=C(O)C=C6)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CSSC[C@@H]1NC([C@H](CC7=CNC8=CC=CC=C78)NC([C@@H](NC([C@H](CCCNC(N)=N)N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[H])=O)=O)=O
Biological Activity: Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges[1].
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Polyphemusin I | Polyphemusin I is a natural antimicrobial peptide with excellent antimicrobial activity against Gram-negative and Gram-positive bacteria. Polyphemusin I contains 18 amino acids and is stabilized into an amphiphilic, antiparallel β-hairpin by two disulfide bridges. | |||||||||||||||||||||
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Keywords