12676-10-7
12676-10-7
Chemical Structure
Albomycin ε
- CAS No.: 12676-10-7
- Formula:C36H56FeN11O17S
- Molecular Weight:1002.80
InChIKey: VQCJCCMAGPCDIK-VUVVNIFUSA-N
SMILES: O[C@H]1[C@H](O)[C@@H](N2C=CC(N(C)C2=O)=N)S[C@@]1([H])[C@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@@H](N3)CCCN(C(C)=O4)O[Fe]546(O7)ON(C(C)=O6)CCC[C@H](NC([C@H](CCCN7C(C)=O5)N)=O)C3=O)=O)=O
Biological Activity: Albomycin ε is a siderophore-antibiotic conjugate targeting bacterial ribosomes (MIC values:>512 μg/mL). Albomycin ε is promising for research of Streptococcus pneumoniae and Staphylococcus aureus infections[1][2].
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Albomycin ε | Albomycin ε is a siderophore-antibiotic conjugate targeting bacterial ribosomes (MIC values:>512 μg/mL). Albomycin ε is promising for research of Streptococcus pneumoniae and Staphylococcus aureus infections. | |||||||||||||||||||||
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References
- [1]. Lin Z, et al. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens. Nat Commun. 2018 Sep 4;9(1):3445. [Content Brief]
- [2]. Gadakh B, et al. Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase. Bioorg Med Chem. 2020 Sep 1;28(17):115645. [Content Brief]
Keywords
