127749-54-6
127749-54-6
Chemical Structure
BMS-182264
- CAS No.: 127749-54-6
- Formula:C15H19N5
- Molecular Weight:269.34
InChIKey: PGYDRGZVXVVZQC-UHFFFAOYSA-N
SMILES: N#CN/C(NC(C(C)(C)C)C)=N\C1=CC=C(C=C1)C#N
Biological Activity: BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia[1][2].
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BMS-182264 | BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia. | |||||||||||||||||||||
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References
- [1]. Dickinson KE, et al. Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells. Eur J Pharmacol. 1998 Mar 12;345(1):97-101. [Content Brief]
- [2]. Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-7. [Content Brief]
Keywords
