1281861-06-0
Chemical Structure
DSM267
- CAS No.: 1281861-06-0
- Formula:C15H12F5N5
- Molecular Weight:357.29
IUPAC Name: 2-(1,1-difluoroethyl)-5-methyl-N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
InChIKey: CUCVTDOXQYMYKL-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=CC=C(C=C1)NC2=CC(=NC3=NC(=NN32)C(F)(F)C)C
Biological Activity: DSM267 is a triazolopyrimidine inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), with an IC50 of 38 nM, while its IC50 against human DHODH exceeds 100000 nM. DSM267 is used for the in vitro systematic screening and characterization of the resistance evolution pathways of Plasmodium falciparum to DHODH inhibitors[1][2].
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DSM267 | DSM267 is a triazolopyrimidine inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), with an IC50 of 38 nM, while its IC50 against human DHODH exceeds 100000 nM. DSM267 is used for the in vitro systematic screening and characterization of the resistance evolution pathways of Plasmodium falciparum to DHODH inhibitors. | |||||||||||||||||||||
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- [1]. Mandt REK, et al. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Sci Transl Med. 2019;11(521):eaav1636. [Content Brief]
- [2]. Deng X, et al. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Acta Crystallogr F Struct Biol Commun. 2015;71(Pt 5):553-559. [Content Brief]
Keywords
