129112-17-0
Chemical Structure
EGFRvIII peptide (PEPvIII)
- CAS 番号: 129112-17-0
- Formula:C70H111N19O24S
- Molecular Weight:1634.81
IUPAC Name: (2R,5S,8S,11S,14S,17S,20S,23S,29S,32S,35S,38S)-5-((1H-imidazol-4-yl)methyl)-23-(2-amino-2-oxoethyl)-38-((S)-2-amino-4-methylpentanamido)-29,32-bis(4-aminobutyl)-35-(2-carboxyethyl)-8-(carboxymethyl)-20-(4-hydroxybenzyl)-11-((R)-1-hydroxyethyl)-14,17-diisopropyl-2-(mercaptomethyl)-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxo-3,6,9,12,15,18,21,24,27,30,33,36-dodecaazahentetracontanedioic acid
InChIKey: SPTJJLROEVHISZ-FNVAVSIXSA-N
SMILES: O=C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)N
Biological Activity: EGFRvIII peptide (PEPvIII) is a tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms and its expression enhances tumorigenicity. EGFRvIII peptide represents a truly tumor-specific target for antitumor immunotherapy[1].
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EGFRvIII peptide (PEPvIII) | EGFRvIII peptide (PEPvIII) is a tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms and its expression enhances tumorigenicity. EGFRvIII peptide represents a truly tumor-specific target for antitumor immunotherapy. | |||||||||||||||||||||
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Keywords
