130717-51-0
130717-51-0
Chemical Structure
FR122047
- CAS No.: 130717-51-0
- Formula:C23H26ClN3O3S
- Molecular Weight:459.99
IUPAC Name: (4,5-bis(4-methoxyphenyl)thiazol-2-yl)(4-methylpiperazin-1-yl)methanone hydrochloride
InChIKey: YWMAVHIKOAOSFM-UHFFFAOYSA-N
SMILES: O=C(C1=NC(C2=CC=C(OC)C=C2)=C(C3=CC=C(OC)C=C3)S1)N4CCN(C)CC4.[H]Cl
Biological Activity: FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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FR122047 | 99.55% | FR122047 (hydrochloride) is a selective and oral active inhibitor of COX-1 with an IC50 of 28 nM. FR122047 hydrochloride has antiplatelet, analgesic and anti-inflammatory effects in vivo. | ||||||||||||||||||||
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References
- [1]. Dohi M, et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. Eur J Pharmacol. 1993 Oct 19;243(2):179-84. [Content Brief]
- [2]. Ochi T, Motoyama Y, Goto T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. Eur J Pharmacol. 2000 Mar 10;391(1-2):49-54. [Content Brief]
- [3]. Ochi T, Goto T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. Br J Pharmacol. 2002 Feb;135(3):782-8. [Content Brief]
Keywords
