1309283-11-1
Chemical Structure
Phenoxybenzamine-d5
- CAS No.: 1309283-11-1
- Formula:C18H17D5ClNO
- Molecular Weight:308.86
IUPAC Name: N-(2-chloroethyl)-1-phenoxy-N-((phenyl-d5)methyl)propan-2-amine
InChIKey: QZVCTJOXCFMACW-FPWDVLCWSA-N
SMILES: CC(COC1=CC=CC=C1)N(CCCl)CC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H]
Biological Activity: Phenoxybenzamine-d5 is the deuterium labeled Phenoxybenzamine[1]. Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity[2][3].
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Phenoxybenzamine-d5 | Phenoxybenzamine-d5 is the deuterium labeled Phenoxybenzamine. Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity. | |||||||||||||||||||||
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Phenoxybenzamine | Phenoxybenzamine is a nonselective, irreversible, orally active α-adrenoceptor antagonist that is commonly used for the research of hypertension, specifically caused by pheochromocytoma. Phenoxybenzamine also shows antitumor activity. | |||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Habbe N, et al. Urapidil in the preoperative treatment of pheochromocytomas: a safe and cost-effective method. World J Surg. 2013 May;37(5):1141-6. [Content Brief]
- [3]. Lin XB, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016 Mar37(3):2901-8. [Content Brief]
Keywords
