134029-48-4
134029-48-4
Chemical Structure
Varacin
- CAS No.: 134029-48-4
- Formula:C10H13NO2S5
- Molecular Weight:339.52
IUPAC Name: 2-(8,9-dimethoxybenzo[f][1,2,3,4,5]pentathiepin-6-yl)ethan-1-amine
InChIKey: HIKCOAGMCNIBMP-UHFFFAOYSA-N
SMILES: O(C=1C=C(C=2SSSSSC2C1OC)CCN)C
Biological Activity: Varacin is a benzopentathiepin polysulfide derived from marine ascidians. It exerts cytotoxic, antibacterial, and antifungal activities by cleaving DNA through a redox pathway. Varacin can be used in research on cancer, fungal infections, and bacterial infections[1][2][3][4].
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Varacin | Varacin is a benzopentathiepin polysulfide derived from marine ascidians. It exerts cytotoxic, antibacterial, and antifungal activities by cleaving DNA through a redox pathway. Varacin can be used in research on cancer, fungal infections, and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Bradley S. Davidson, Tadeusz F. Molinski, Louis R. Barrows, Chris M. Ireland; Varacin: a novel benzopentathiepin from Lissoclinum vareau that is cytotoxic toward a human colon tumor. Journal American Chemical Society 1 June 1991; 113 (12): 4709-4710.
- [2]. Pozzetti L, et al. Pentathiepins are an understudied molecular prism of biological activities. Archiv der Pharmazie. 2024 Dec;357(12):e2400646.
- [3]. Makarieva TN, et al. Varacin and three new marine antimicrobial polysulfides from the far-eastern ascidian Polycitor sp. Journal of natural products. 1995 Feb;58(2):254-8.
- [4]. Paul W. et al. Synthesis of varacin, a cytotoxic naturally occurring benzopentathiepin isolated from a marine ascidian. Journal of Organic Chemistry 1 August 1993; 58 (17): 4522-4523.
