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Cat. No.: HY-N21817

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Varacin

Varacin is a benzopentathiepin polysulfide derived from marine ascidians. It exerts cytotoxic, antibacterial, and antifungal activities by cleaving DNA through a redox pathway. Varacin can be used in research on cancer, fungal infections, and bacterial infections.

For research use only. We do not sell to patients.

CAS No.: 134029-48-4
Formula: C₁₀H₁₃NO₂S₅
Molecular Weight:339.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Varacin Chemical Structure

CAS No.: 134029-48-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC90	0.05 μg/mL	Inhibition of human colon cancer HCT 116 cell growth measured via cytotoxicity assay. Inhibition of human colon cancer HCT 116 cell growth measured via cytotoxicity assay.	>

In Vitro

Varacin (compound 1) (2 μg per disk) exhibits potent antifungal activity against Candida albicans, producing an inhibition zone of 14 mm^[1].
Varacin (2 µg per disk) exhibits antifungal activity against Candida albicans, producing a 14 mm inhibition zone at a paper disk loading of 2 µg^[2].
Varacin (0.05 μg/mL) potently inhibits the growth of human colon cancer HCT 116 cells, with an IC₉₀ of 0.05 μg/mL^[1].
Varacin exhibits 1.5-fold greater cytotoxicity against CHO EM9 cells than against CHO BR1 cells, indicating its potential DNA-damaging activity^[1].
Varacin exerts potent cytotoxic effects on human colon cancer HCT116 cells, with a IC₉₀ of 0.05 µg/mL^[2].
Varacin induces cytotoxicity in 8 different human cancer cell lines, with IC₅₀ values ranging from 0.60 nM to 48.40 nM^[2].
Varacin (0.1 μg) exhibits antibacterial activity against Bacillus subtilis in vitro, with an inhibition zone diameter of 20 mm at a concentration of 0.1 μg; meanwhile, it shows antifungal activity against Candida albicans, with an inhibition zone diameter of 20 mm at a concentration of 0.1 μg^[3].
Varacin exhibits significant cytotoxic activity against the human colon cancer cell line HCT 116, along with notable antifungal activity; preliminary evidence indicates that DNA-damaging activity serves as its underlying cytotoxic mechanism of cytotoxicity^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 134029-48-4
Molecular Weight 339.52
Formula C₁₀H₁₃NO₂S₅
SMILES

O(C=1C=C(C=2SSSSSC2C1OC)CCN)C
Structure Classification
- Others
Initial Source
- Animals
Lissoclinum vareau
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bradley S. Davidson, Tadeusz F. Molinski, Louis R. Barrows, Chris M. Ireland; Varacin: a novel benzopentathiepin from Lissoclinum vareau that is cytotoxic toward a human colon tumor. Journal American Chemical Society 1 June 1991; 113 (12): 4709-4710.

[2]. Pozzetti L, et al. Pentathiepins are an understudied molecular prism of biological activities. Archiv der Pharmazie. 2024 Dec;357(12):e2400646.

[3]. Makarieva TN, et al. Varacin and three new marine antimicrobial polysulfides from the far-eastern ascidian Polycitor sp. Journal of natural products. 1995 Feb;58(2):254-8.

[4]. Paul W. et al. Synthesis of varacin, a cytotoxic naturally occurring benzopentathiepin isolated from a marine ascidian. Journal of Organic Chemistry 1 August 1993; 58 (17): 4522-4523.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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