135038-59-4
Chemical Structure
Alatrioprilat
- CAS No.: 135038-59-4
- Formula:C14H17NO5S
- Molecular Weight:311.35
IUPAC Name: ((S)-3-(benzo[d][1,3]dioxol-5-yl)-2-(mercaptomethyl)propanoyl)-L-alanine
InChIKey: TXSINLUUGRGAJO-WCBMZHEXSA-N
SMILES: OC([C@H](C)NC([C@@H](CS)CC1=CC=C(OCO2)C2=C1)=O)=O
Biological Activity: Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases[1].
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Alatrioprilat | Alatrioprilat is an orally active inhibitor of angiotensin-converting enzyme (ACE) (IC50=19.6 nM; Ki=9.8 nM) and enkephailnase (IC50=6.1 nM; Ki=5.1 nM). Alatrioprilat plays a key role in the metabolism of hormonal peptides through the degradation of nitric oxide and atrial natriuretic factor (ANF). Alatrioprilat can be used in the study of cardiovascular diseases. | |||||||||||||||||||||
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- [1]. Gros C, et al. Mixed inhibitors of angiotensin-converting enzyme (EC 3.4. 15.1) and enkephalinase (EC 3.4. 24.11): rational design, properties, and potential cardiovascular applications of glycopril and alatriopril[J]. Proceedings of the National Academy of Sciences, 1991, 88(10): 4210-4214. [Content Brief]
Keywords
