1351116-34-1
Chemical Structure
KI-TOX-A3
- CAS No.: 1351116-34-1
- Formula:C18H13N3O3
- Molecular Weight:319.31
InChIKey: XGSXAHYOOFFVOF-UHFFFAOYSA-N
SMILES: OCC1=CC=C(C2=C(CC3=C4C=CC(O)=C3)C4=NC(N)=C2C#N)O1
Biological Activity: KI-TOX-A3 is a TOX protein-protein interaction inhibitor that blocks the TOX-KAT7 protein-protein interaction with an IC50 of 0.51 μM. KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses exhaustion of CD8+ T cells, and inhibits the proliferation of T cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for use in studies of hematological malignancies such as T-ALL[1].
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KI-TOX-A3 | 99.15% | KI-TOX-A3 is a TOX protein-protein interaction inhibitor that blocks the TOX-KAT7 protein-protein interaction with an IC50 of 0.51 μM. KI-TOX-A3 induces proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses exhaustion of CD8+ T cells, and inhibits the proliferation of T cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 shows promise for use in studies of hematological malignancies such as T-ALL. | ||||||||||||||||||||
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Keywords
