1352477-26-9
Chemical Structure
h-FTAA
- CAS No.: 1352477-26-9
- Formula:C34H20O8S7
- Molecular Weight:780.97
InChIKey: JXMVXIHCLMHELZ-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC=C(C3=CC(CC(O)=O)=C(C4=CC=C(C5=C(CC(O)=O)C=C(C6=CC=C(C7=CC=C(C(O)=O)S7)S6)S5)S4)S3)S2)S1)O
Biological Activity: h-FTAA is a luminescent conjugated oligothiophene (LCO) probe. h-FTAA can selectively bind to amyloid protein aggregates (such as Aβ plaques) and distinguish different conformations of the protein aggregates through changes in fluorescence signals. h-FTAA significantly reduces the neurotoxicity of Aβ1-42 and the Arctic mutant Aβ (AβArc), thereby protecting SH-SY5Y neuroblastoma cells. h-FTAA can be used to dynamically track the formation and maturation process of Aβ plaques[1][2].
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h-FTAA | 98.0% | h-FTAA is a luminescent conjugated oligothiophene (LCO) probe. h-FTAA can selectively bind to amyloid protein aggregates (such as Aβ plaques) and distinguish different conformations of the protein aggregates through changes in fluorescence signals. h-FTAA significantly reduces the neurotoxicity of Aβ1-42 and the Arctic mutant Aβ (AβArc), thereby protecting SH-SY5Y neuroblastoma cells. h-FTAA can be used to dynamically track the formation and maturation process of Aβ plaques. | ||||||||||||||||||||
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- [1]. Sandin L, et al. The Luminescent Conjugated Oligothiophene h-FTAA Attenuates the Toxicity of Different Aβ Species. Biochemistry. 2021 Sep 21;60(37):2773-2780. [Content Brief]
- [2]. Wood JI, et al. Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model. Nat Commun. 2025 Sep 1;16(1):8170. [Content Brief]
Keywords
