1355228-38-4
1355228-38-4
Chemical Structure
K811
- CAS No.: 1355228-38-4
- Formula:C29H26N4O5
- Molecular Weight:510.54
InChIKey: JVQKIXBAOVAPKB-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C(C)C)C2=C(C1=O)C=CC=C2)NC3=CC=C(C=C3)OC4=CN=NC5=CC(OC)=C(C=C54)OC
Biological Activity: K811 is an orally active ASK1 inhibitor with an IC50 of 6 nM. K811 inhibits glial cell activation in the lumbar spinal cord of SOD1G93A transgenic mice. K811 extends the survival of SOD1G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis. K811 can be used in studies related to amyotrophic lateral sclerosis[1].
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K811 | K811 is an orally active ASK1 inhibitor with an IC50 of 6 nM. K811 inhibits glial cell activation in the lumbar spinal cord of SOD1G93A transgenic mice. K811 extends the survival of SOD1G93A transgenic mice, a mouse model of amyotrophic lateral sclerosis. K811 can be used in studies related to amyotrophic lateral sclerosis. | |||||||||||||||||||||
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References
Keywords
