1356053-63-8
1356053-63-8
Chemical Structure
BMS-737
- CAS No.: 1356053-63-8
- Formula:C16H11FN6
- Molecular Weight:306.30
InChIKey: OEVSKJAZBGCGII-UHFFFAOYSA-N
SMILES: FC1=CC=C(N2N=CC3=C(C4=C(N)N=CN=C4)C=CN=C32)C=C1
Biological Activity: BMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels[1].
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BMS-737 | BMS-737 (compound 33) is a non-steroidal, reversible small molecule inhibitor. BMS-737 exhibits 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase. BMS-737 is designed to inhibit castration-resistant prostate cancer (CRPC) and significantly reduces testosterone levels without significant effects on orrodermal hormone and glucocorticoid levels. | |||||||||||||||||||||
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References
Keywords
