1369302-24-8
Chemical Structure
IPG-2 AM
Synonym(s): APG-2 Acetoxymethyl ester
- CAS No.: 1369302-24-8
- Formula:C55H64Cl2N2O19
- Molecular Weight:1128.00
InChIKey: FLNBWSAACUIXPZ-UHFFFAOYSA-N
SMILES: O=C(C)OCOC(CCC1=CC2=C(C3=CC(OC)=C(N4CCOCCOCCN(CCOCCOCC4)C5=CC=C(C)C=C5OC)C=C3)C6=C(C(Cl)=C(C(CCC(OCOC(C)=O)=O)=C6)OCOC(C)=O)OC2=C(C1=O)Cl)=O
Biological Activity: IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics[1][2].
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IPG-2 AM | IPG-2 AM (APG-2 Acetoxymethyl ester) is a membrane-permeant acetoxymethyl ester derivative and selective fluorescent potassium ion indicator. IPG-2 AM exhibits fluorescence increases proportional to extracellular potassium ion concentrations. IPG-2 AM enables real-time monitoring of cytosolic free potassium ion fluxes in human platelets and macrophages. IPG-2 AM can be used for the research of intracellular potassium concentration dynamics. | |||||||||||||||||||||
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[1]. Mazzarda F, et al. Inflammasome activation and IL-1β release triggered by nanosecond pulsed electric fields in murine innate immune cells and skin. The Journal of Immunology. 2024 Jan;212(2):335-45.
- [2]. Aliotta A, et al. Flow Cytometric Monitoring of Dynamic Cytosolic Calcium, Sodium, and Potassium Fluxes Following Platelet Activation. Cytometry A. 2020;97(9):933-944. [Content Brief]
Keywords
