137927-14-1
Chemical Structure
TY-11345
- CAS 番号: 137927-14-1
- Formula:C18H19N3NaO2S
- Molecular Weight:364.42
IUPAC Name: 9-((1H-benzo[d]imidazol-2-yl)sulfinyl)-4-methoxy-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine, sodium salt
InChIKey: PWGFYXJHFWTGJX-UHFFFAOYSA-N
SMILES: O=S(C1C2=NC=CC(OC)=C2CCCC1)C3=NC4=C(N3)C=CC=C4.[Na]
Biological Activity: TY-11345 is an orally active gastric mucosal H+/K+-ATPase inhibitor, with IC50 values of 5.8 μM (Reference 1) and 3.3 μM (Reference 2) at pH 6.0, respectively. TY-11345 inhibits basal gastric acid secretion stimulated by Tetragastrin (HY-125556) and Pentagastrin (HY-A0261), and prevents gastric and duodenal injuries in rats. TY-11345 can be used in the research of peptic ulcer disease and acid-related gastrointestinal diseases[1][2].
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TY-11345 | TY-11345 is an orally active gastric mucosal H+/K+-ATPase inhibitor, with IC50 values of 5.8 μM (Reference 1) and 3.3 μM (Reference 2) at pH 6.0, respectively. TY-11345 inhibits basal gastric acid secretion stimulated by Tetragastrin (HY-125556) and Pentagastrin (HY-A0261), and prevents gastric and duodenal injuries in rats. TY-11345 can be used in the research of peptic ulcer disease and acid-related gastrointestinal diseases. | |||||||||||||||||||||
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- [1]. Yamaguchi T, et al. Biochemical and pharmacological properties of a newly synthesized proton pump (H+/K(+)-ATPase) inhibitor, TY-11345 in experimental animals. Japanese journal of pharmacology. 1993 Aug;62(4):363-71. [Content Brief]
- [2]. Yamada S, et al. Synthesis and antiulcer activities of novel 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H- benzimidazole analogues. Chemical & pharmaceutical bulletin. 1994 Mar;42(3):718-20. [Content Brief]
Keywords
