Synthesis and antiulcer activities of novel 2-[(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)sulfinyl]-1H- benzimidazole analogues

  • Chem Pharm Bull (Tokyo). 1994 Mar;42(3):718-20. doi: 10.1248/cpb.42.718.
S Yamada  1 ,  T Goto ,  E Shimanuki ,  S Narita
Affiliations
  • 1. Fukushima Research Laboratories, TOA EIYO Ltd., Fukushima, Japan.
PMID: 8004722 DOI: 10.1248/cpb.42.718
Abstract

A synthetic study on a series of benzimidazole derivatives including cycloalka[b]pyridine moiety has been carried out. Among these compounds synthesized, a novel antipeptic agent with 6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridine moiety (TY-11345) was found to be superior to omeprazole in (H+ + K+)-ATPase inhibitory activity and antisecretory potencies.

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